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Accounting software like QuickBooks Pro (QBP) treats an invoice and a statement differently. If you try to use them interchangeably, you will wreak havoc on your company's financial records. The difference is simple: An invoice is a record of an individual transaction, while a statement is a summary of all account activity during a given billing cycle. For example, if you charge a box of screws and some copper plumbing fittings to your account at the local hardware store, the sale is recorded on an invoice. You can request separate invoices for each item — if the screws were for the Smith job, for instance, and the copper fittings were for the Jones job — but the invoices